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Symbol
Name
ID 		Tgfb1
transforming growth factor, beta 1
MGI:98725
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgG level
Decreased circulating antibody level
Paraproteinemia
Eosinophilia
Sinusitis
Chronic sinusitis
Allergic rhinitis
Conjunctivitis
Lymphadenopathy
Splenic rupture
Splenomegaly
Hepatosplenomegaly
Esophagitis
Pancreatitis
Iridocyclitis
Epididymitis
Eczematoid dermatitis
Atopic dermatitis
Erythema nodosum
Recurrent skin infections
Recurrent pneumonia
Asthma
Nontuberculous mycobacterial pulmonary infection
Recurrent Burkholderia cepacia infections
Recurrent Haemophilus influenzae infections
Recurrent Staphylococcus aureus infections
Recurrent Aspergillus infections
Recurrent respiratory infections
Recurrent bronchopulmonary infections
Recurrent lower respiratory tract infections
Disease(s) Associated with TGFB1
asthma
atopic dermatitis
Behcet's disease
cystic fibrosis
eosinophilic esophagitis
factor VIII deficiency
multiple myeloma

Mouse Phenotypes
immune system phenotype
phlebitis
heart inflammation
atrial endocarditis
myocarditis
pericarditis
increased T cell proliferation
large intestinal inflammation
cecum inflammation
colitis
proctitis
small intestinal inflammation
salivary gland inflammation
stomach inflammation
decreased thymus weight
thymus hypoplasia
lacrimal gland inflammation
pancreas inflammation
abnormal T cell differentiation
abnormal T-helper 17 cell differentiation
decreased Langerhans cell number
absent Langerhans cell
abnormal T cell subpopulation ratio
increased T-helper 1 cell number
decreased T-helper 17 cell number
decreased CD4-positive, alpha-beta T cell number
increased CD4-positive, alpha-beta T cell number
increased regulatory T cell number
increased monocyte cell number
increased leukocyte cell number
abnormal T cell morphology
decreased spleen weight
small spleen
spleen hypoplasia
abnormal T cell activation
abnormal regulatory T cell physiology
abnormal interferon level
abnormal interleukin level
abnormal immune system organ morphology
abnormal Peyer's patch germinal center morphology
decreased Peyer's patch number
enlarged lymph nodes
abnormal immune system physiology
lymph node inflammation
increased interferon-gamma secretion
increased interleukin-2 secretion
decreased susceptibility to experimental autoimmune encephalomyelitis
increased anti-nuclear antigen antibody level
increased anti-double stranded DNA antibody level
abnormal inflammatory response
increased inflammatory response
brain inflammation
diaphragmitis
eye inflammation
conjunctivitis
liver inflammation
myositis
lung inflammation
interstitial pneumonia
skin inflammation
Availability Mouse Genotype
Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul *
Tgfb1tm1Doe/Tgfb1tm1Doe !
Tgfb1tm1N/Tgfb1tm1N
Tgfb1tm1Rif/Tgfb1tm1Rif
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?  (conditional)
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(Cd4-cre)1Cwi/0  (conditional)
Tg(Lck-cre)548Jxm/?
Tgfb1tm2.1Doe/Tgfb1tm2.1Doe  (conditional)
Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0  (conditional)
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tg(Cd4-cre)1Cwi/0  (conditional)
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tnfrsf4tm2(cre)Nik/Tnfrsf4+  (conditional)
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Foxp3tm4(YFP/icre)Ayr/Foxp3+  (conditional)		 *
Tgfb1tm1Doe/Tgfb1tm2.1Doe
Tg(Lck-cre)548Jxm/?  (conditional)
Tgfb1tm2Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory